OPTIMIZE HEALTH

“So roughly 30% of the revenue generated by the insurance companies, United, Cigna, Aetna, Blue Cross Blue Shield, who are multi-billion dollar conglomerates, these companies, 30% of the revenue comes from rebates on prescription drugs.”

“If you want to perform better, recover stronger, and build a body that lasts, you have to start by getting the fundamentals right.”

“The reason that those sales have exceeded our expectations is people are taking into their own hands their future. People are basically voting with their feet saying, I'm done waiting to reactively go and treat myself for the diseases that I backward-lookingly manifest. I'm ready to go get after and help myself to live longest and fullest.”

“GLP-1 medicines are showing us what happens when we get to the root of disease. These medicines have the potential to do everything from protect us from being diabetic after being pre-diabetic all the way through lowering our risk of having a heart attack or a stroke. Protecting our kidneys and soon we're going to see the opportunity to protect us from developing addictions to alcohol and drugs. So an a profoundly important single medicine because these medicines are incredibly powerful and they can do wonders for people's long-term health.”

“The gap is not necessarily needing more medicines. It's actually pointing those medicines at the impact that they can have. And so to me, what I'm excited about about the GOP1 opportunity is we're seeing the first commercial proof that we're ready to head in that direction. The reason that those sales have exceeded our expectations is people are taking into their own hands their future. People are basically voting with the feet saying, 'I'm done waiting to reactively go and treat myself for the diseases that I backward-lookingly manifest. I'm ready to go get after and help myself to live longest and fullest.'”

“So so many modalities, like a plasmapheresis. Most Americans have no clue what that is. Yeah. Plasmapheresis has been around 50 years... But historically, they have never used it for preventative care.”

“All of these axes that I define as the five key layers to defense to the defensive side of a health stack, each of them has medicines available to help us control our fate. Each of them has medicines available that if we could get on them early and be proactive about where we're going with our health, they will undoubtedly add an extra decade of life to our expected lifespan and have the potential to take curves that have been dead flat for decades and drive one of the first inflections ever.”

“Next, melan too. And this will actually end up giving you a deep tan in response to just a little bit of UV sun exposure. It'll also give you some of the most impressive erections you've ever had in your life. So, be warned. And what else have we got? Oh my gosh. There's methyline blue where people take it and they think it's going to make them live forever. Don't take this.”

“In 2013 there was actually a court case in the United States. It was the Myriad Genetics case. The Supreme Court actually sided with that argument saying that if something is natural, it's found within us. I can't patent you know your muscle cells, right? Which is a wonderful thing. But the unintentional byproduct of that is all of a sudden pharma had no incentive whatsoever to pursue really promising compounds that they could not monetize.”

“Peptides are a structural class of medications. The best way to think about peptides is that just like we have small molecules which are drugs that are very small taken in a pill and have a wide ranging effect throughout the body. Peptides are derived from little pieces of amino acids which think of them as the Legos that make up the human body. The Legos that make up proteins. These are fragments of proteins that are designed to specifically target certain receptors and affect cells in a very targeted fashion.”

“And we have medicines today, whether they're statins, the PCSK9 inhibitors, that can do wonders to reduce our level of cholesterol. And most middle-aged men and women walking around have somewhere between a 30% and a 50% probability of having a heart attack and a stroke... we have the medicines that exist that can help us to dramatically lower that risk to sub 10%.”

“So they go to the big pharmaceutical company like Lilly and they go, hey, instead of selling it for 150, sell it to us for 300, give us $150 rebate. The rebate stays at the middleman company. At the end of the year, the insurance company bills the employer for the 300 dollars.”

“BPC-157 is a synthetic version of a naturally found peptide in the gut. But what this actually does is it enhances blood vessel growth in areas of injury. And it kind of makes sense because if you think about it, our gut, our stomach is really just this bag of acid that sits inside of our abdomen. And yet somehow you and I are here talking to each other and our bodies aren't eating themselves. Well, how does that work? Well, it's because we've developed a lot of really robust systems to encourage healing of the gastric lining.”

“What gets me fired up about that is not necessarily this once-in-a-decade $100 billion revenue opportunity that exists within GLP-1s. What gets me fired up is that it's actually the first commercial proof that we are ready for what I think we're going to look back on in time as a once-in-a-lifetime trillion-dollar revolution in all of public health.”

“And the problem with the health care system is it's a sick care system that is monetizing chronic disease. And insurance companies are one of the key players in this. Insurance companies are not there to keep you healthy and prevent chronic disease. Insurance are there to manage medications and to monetize chronic disease.”

“I think one of the things a lot of people don't appreciate when I meet them and we start talking about where medicine is and what it can do is that incredible scientists have already cracked the code on most of the medicines we need to protect us from most of the diseases that will claim most of our lives.”

“Moving down to neurocognitive health. The data is not out yet, but later on this year, we're going to see the next step for what are called anti-amaloid medicines. Medicines that can go right at the heart of the accumulation of plaques. This time not in our vasculature, but but in our brains that lead to all sorts of damage and cognitive decline. And we've got medicines today that can go right at those plaques and bust them. And what Lily is going to probably show later on this year... is that getting at those plaques earlier before they accumulate as significantly is going to show dramatic effects on protecting us from developing Alzheimer's.”

“The goal is to achieve wellness, not to treat chronic disease. Now I've gotten used to it, because it does, I do think it's encompassing of what we're trying to achieve. The goal is to achieve wellness, not to treat chronic disease.”

“What a health stack looks like has a couple of different elements to it. It has elements of offense and defense... To me, the five key layers are lipid optimization, its cardiometabolic health, it is neurocognitive health, it is inflammatory health, and our blood pressure.”

“If you want to perform better, recover stronger, and build a body that lasts, you have to start by getting the fundamentals right.”

“When we think about the lipid optimization, we have and our bodies produce cholesterol. And there's a type of cholesterol called your LDL cholesterol that's really dangerous. And it's dangerous because this cholesterol builds up in our bodies over time. And it's slowly accumulating in our vasculature. And as it accumulates, it gets to a point where it causes a blockage. That's a heart attack and a stroke. And we have medicines today, whether they're statins, the PCSK9 inhibitors, that can do wonders to reduce our level of cholesterol. And most middle-aged men and women walking around have somewhere between a 30 and a 50% probability of having a heart attack and a stroke sometime between the time that they turn 40 and the time that they turn 80.”

“This is a peptide that absolutely torches belly fat at a disproportionate rate. And what we found is not only do patients lose an incredible amount of weight, but they also get the best improvements we've ever seen in their liver health. It's absolutely wild. And I think this is going to be a trillion dollar drug when it comes out. And I brought you here because you're an expert on this subject matter.”