DRINK COFFEE

“So people that drank Robusta coffee lowered their double-stranded breaks by 23 percent compared to just drinking like water, which is pretty robust. So it's kind of cool, right? Again, it was like caffeinated coffee. It wasn't decaf.”

“Coffee will acutely raise your blood glucose levels. And in fact, I've measured that in myself, wearing my CGM. Yes, you will get an acute raise in your blood glucose levels from coffee. You're getting sympathetic activation. But over the long term, it's actually beneficial. Both caffeine and the polyphenols in coffee, the chlorogenic acids, activate AMP kinase, this master regulator, this sort of metabolic sensor that is activating all sorts of energy pathways.”

“By the way, how crazy is it that you don't have to state on the Starbucks anything how much caffeine it is? In energy drinks, it's super specific. Here's the exact milligram amount, and you have to be like plus minus like 10 percent. But in coffee, it's like the variability is... I don't know if I saw it from you or somebody else, but there was like a study where the... Even going to the same Starbucks on different days, it was the shift of like hundreds of milligrams of caffeine.”

“Remarkably, compared to those who had very little or no caffeine, the participants consuming greater than equal 400 milligrams per day had 40.2% lower risk of developing multiple cardiometabolic diseases over time. And that risk reduction was greater than the risk reduction in the high consumption coffee or tea groups alone. So it was pretty close to the risk reduction in those consuming 200 to 300 milligrams per day of straight caffeine in the groups that were having 400 or higher.”

“When it comes to Parkinson's disease, you know, Parkinson's disease is you're losing dopamine producing neurons, so dopaminergic neurons in a certain part of the brain called the substantiate negra. And so, what's really interesting is that the adenosine receptors is a key role in this here, in this Parkinson's story, because people that drink caffeinated coffee can reduce their Parkinson's disease risk by up to 60 percent, which is huge for me, because Parkinson's disease is, runs in my family. My dad has Parkinson's disease.”

“Another very interesting finding that I came across when doing a deep dive on this was people that were consuming caffeinated coffee actually had benefits on reducing arrhythmia versus people doing decaf, which is the complete opposite of what you would think or hypothesize or even hear prescriptive, right? So people think that caffeinated coffee causes arrhythmia. In fact, it was the caffeinated coffee that was decreasing arrhythmia risk. Decaf coffee did not do that at all.”

“I do think there's a limit. So there have been studies at least looking at neurodegenerative disease risk, like Alzheimer's disease risk in coffee consumption. And when people started to get up to like eight cups a day, they were actually in, they were like doubling their risk of Alzheimer's disease.”

“I think one of the tough things about these caffeine studies, often when they're establishing like safety parameters, is it's based on like body weight measurements per milligram per kilogram. So then it'll be like some recommendation for a 225 pound guy who's, you know, maybe a fast caffeine metabolizer and, you know, has the capacity to like handle it is stuck using less than 400 because he thinks he's at like elevated risk of like a heart attack with certainty because of some guideline written around like an 150 pound female or something.”