AVOID NAD IVS

“The main reason why NAD declines is because that main enzyme, that NAMPT enzyme in the salvage pathway that makes and recycles NAD from these precursors declines with age. It's kind of like, if you go in a factory and saw production's gone down, you realize that the machines weren't working; there's no way that you would think it would just be a good idea to just keep on loading the factory with raw material and hope you're gonna get more NAD out at the end.”

“We saw a reversal of biological age. This was measured using the glycan age test of 1.26 years in 28 days as well. So we know that this is improving all around cellular health. In this study, we didn't measure any sort of clinical outcomes in terms of disease status, but we saw significant reduction in levels of GSP in just 28 days.”

“This Apigenin is actually a really, really good inhibitor of CD38. And that's important for two reasons. The first, we don't want to waste NAD, but perhaps the even more important reason is when you are boosting NAD, everyone's boosting it because they want it to switch on repair or activate the sirtuins. But the reality is that if you have any inflammation in your body, CD38 has what we call a high affinity for NAD and will grab it before the beneficial things even get a look in.”

“There's a paper that's been released that showed within NAD IVs in a human clinical trial that it actually causes an inflammatory reaction. So they saw an increase in white blood cells, neutrophils, cytokines. You put in a huge amount of an intracellular molecule outside the cell, the body's going to think, what the heck has happened? Is there a trauma? Is there some damage? And it elicits an unspecific inflammatory reaction to deal with whatever the perceived stress is.”

“When scientists realize that NAD actually declines with age quite substantially, so it's estimated a half every 20 years, and this is from birth. So even by the time you're 20, it's half, then by the time you're 40, it's half again. What they realized was that, okay, this molecule that's actually very important for keeping our repair switched on, declines significantly with age, so why don't we prevent this decline?”

“For one cycle of CD38 enzymatic activity, it uses around 100 molecules of NAD just for one cycle. For something like the DNA repair enzymes or the sirtuins, they use about six or seven. So you can see that a very small increase in inflammation can have a huge impact on NAD levels.”

“If you are ignoring these problems and you are ploughing loads of precursors into the cell, whether that's oral NR or IV NR or it's NMN, that will be getting made into NAD, it will be getting used once, it will be getting broken down in nicotinamide, and then this nicotinamide is just building up and building up because your cells can't do anything with it. And then the methylation problem starts to happen.”

“Rutin actually is a direct activator of NAMPT, so it directly switches on its expression. And then the other one that we use is alpha lipoic acid. And alpha lipoic acid is an indirect activator. The way that this works is it actually switches on something in our cells called AMPK, which is an energy sensor that tells ourselves to produce more NAMPT.”