Invest Like the Best with Patrick O'Shaughnessy
from: Invest Like the Best with Patrick O'Shaughnessy
Colossus | Investing & Business Podcasts
PUBLISHED: APR 14, 2026INDEXED: APR 15, 2026, 12:04 AM

Scott Nolan - SpaceX, Founders Fund, and Rebuilding American Uranium Enrichment - [Invest Like the Best, EP.467]

Key Takeaways

  • General Matter rebuilds domestic uranium enrichment capacity

    General Matter is attacking one of the most interesting bottlenecks in The United States, the enrichment of uranium to create power in nuclear power plants. We don't do any of that in The United States today. We've outsourced it overseas for years. Scott and general matter are seeking to reverse that through the enrichment of uranium here in The United States.

    Patrick O'Shaughnessy
  • The US relies heavily on Russian uranium imports

    Today roughly a quarter of US enriched uranium comes from Russia, a ban on those imports takes full effect in 2028, and the advanced reactors everyone is counting on to power the next wave of data centers have no reliable domestic fuel source. Scott believes enrichment is the single bottleneck to a nuclear future, and that the window to solve it is narrow.

    Patrick O'Shaughnessy
  • Founder control is essential for long-term industrial success

    VC needs innovation. The incumbents won't do it. And circa 2005, the concept was founder friendly. If you looked at all the most successful companies, they were founder run all the way to the end. And so the premise was let's give founders back control of their companies and unilaterally support them in building that.

    Scott Nolan
  • Investing in physical atoms offers massive untapped alpha

    He was starting to already thinking about this probably even more than he was talking about and probably thinking which companies are doing this well. He was talking a lot about we'd made all this progress in the world of bits, but not in the world of atoms. You could be on your cell phone, and it was interesting. And then you look around, and nothing's changed in fifty years.

    Scott Nolan
  • Avoiding trends minimizes competition and maximizes returns

    Number one was it was just avoiding trends, avoiding the herd, thinking for yourself. Whenever we looked at any companies, Peter always took a very orthogonal view to most people. Instead of just doing a spreadsheet and trying to analyze this investment, why don't we think about why are we even seeing this investment?

    Scott Nolan
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Episode Description

Scott Nolan spent 12 years at Founders Fund looking for the most important problems that no one else was funding. Then he found a problem so critical, and so ignored, that he couldn't find a company to back. So he started one. General Matter is rebuilding US uranium enrichment. The United States was the world leader in enrichment through the 1980s and then stopped entirely. Today roughly a quarter of US enriched uranium comes from Russia, a ban on those imports takes full effect in 2028, and the advanced reactors everyone is counting on to power the next wave of data centers have no reliable domestic fuel source. Scott believes enrichment is the single bottleneck to a nuclear future, and that the window to solve it is narrow. The conversation covers how Peter Thiel influenced him, why being in love with an idea is dangerous for investors but required for founders, and what it actually takes to rebuild an industrial capability the country let atrophy for 40 years. Please enjoy my conversation with Scott Nolan. For the full show notes, transcript, and links to mentioned content, check out the episode page ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠.  ----- Become a Colossus member to get our quarterly print magazine and private audio experience, including exclusive profiles and early access to select episodes. Subscribe at ⁠colossus.com/subscribe⁠. ----- ⁠Ramp’s⁠ mission is to help companies manage their spend in a way that reduces expenses and frees up time for teams to work on more valuable projects. Go to⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠ramp.com/invest⁠⁠ to sign up for free and get a $250 welcome bonus. ----- Trusted by thousands of businesses, ⁠Vanta⁠ continuously monitors your security posture and streamlines audits so you can win enterprise deals and build customer trust without the traditional overhead. Visit ⁠vanta.com/invest⁠.  ----- ⁠WorkOS⁠ is a developer platform that enables SaaS companies to quickly add enterprise features to their applications. Visit⁠⁠ ⁠WorkOS.com⁠⁠⁠ to transform your application into an enterprise-ready solution in minutes, not months. ----- Rogo is the AI platform for finance. They're building agents for Wall Street that are trained to understand how bankers and investors actually do work: from diligence and modeling, to turning analysis into deliverables. To learn more, visit rogo.ai/invest. ----- ⁠Ridgeline⁠ has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. Visit⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ridgelineapps.com⁠. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thepodcastconsultant.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠). Timestamps: (00:00:00) Welcome to Invest Like The Best (00:02:45) Guest Intro: Scott Nolan (00:03:36) SpaceX, Founders Fund & General Matter (00:08:04) What Scott learned from Peter Thiel (00:10:05) The "Avoid Trends" Concept (00:10:55) Finding Important Problems No One Is Working On (00:17:32) Gut v. Intuition (00:18:49) Valuation, Competition & Capital Intensity (00:20:20) Founders Fund Strategy (00:21:06) The Steeper the Up Round, the Greater the Undervaluation (00:21:41) Being in Love with the Problem (00:26:07) Governments, Technology & History (00:28:54) Lessons from SpaceX and Elon (00:29:42) Vertical Integration (00:33:07) The Role of Energy in Civilization (00:37:36) State & Direction of US Energy (00:38:58) Why Nuclear? (00:42:20) Taxonomy of Advanced Reactors (00:45:33) The BYOE Concept (00:46:50) What Could Make Advanced Reactors Fail? (00:48:04) General Matter: Product, Business & Company (00:50:12) Enrichment & Weapons-Grade Uranium (00:56:45) North Star Metric (01:01:05) Building a Great Enduring Company (01:04:01) How Scott Runs the Company (01:06:11) Overcoming Irrational Fears About Nuclear (01:08:25) Why Aren't There More Founders Funds? (01:10:03) Operating vs. Investing (01:11:56) Kindest Thing

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