“Your DNA makes up about 20% of your health outcome, but the other 80% is what you do, what you eat, how you sleep, your stress levels. With epigenetics, you're measuring that. That other 80%, you're actually looking at how much every gene is turned up and turned down. What we can predict with epigenetics is limited by our imagination and the size of the data set.”
“The Dunedin PACE. That is my favorite of the biologic age test. It’s developed by Duke and it has actually been shown to be the best predictor of morbidity and mortality period. There was a really big trial called the BASE-2 trial that just came out in the last month. And it is better than Grip Strength, VO2 Max, and all the other things.”
“We found 1600 biomarkers we could predict when we measured them against their traditional versions. About two-thirds performed better. So better hazard ratio or odds ratio. So we found about a thousand, quote-unquote, upgraded biomarkers. And that's how we developed the TruHealth test. It's the top 100 or so of the ones that actually are better at predicting disease than the traditional LabCorp request versions.”
“I basically built an AI coach for myself that I would feed in all my TruHealth data, all the stuff that we're going to talk about, all my training data, my lactate threshold stuff. It would come up with a plan, come up with a supplement plan, come up with everything, and every day, I would upload my workout that I did and it would adjust.”
“The number one intervention over everything I'll ever tell you about—whether we studied this supplement or this medication—none of that is close to the strength of your social relationships. That study was so definitive that anyone who's biohacking and not focusing on that is wasting their time with everything else.”
“Just like an intense exercise, you're going to have liver function tests from acute stress after and CRP, all these things, but we know then two days later, it was a good thing for us. It really looked like a picture of just like there was a little bit of designed overreaching or some other stressful thing during that one test.”
“We are actually coming out, we're going to be more, we actually have some incredible diagnostics and predictors for actual diseases and we're moving down the reimbursement pathway. We have a predictor for dementia, of are you going to get dementia in the next five years, that has an AUC of over 0.9—so over 90% ability to discriminate that.”
“Your DNA makes up about 20% of your health outcome, but the other 80% is what you do, what you eat, how you sleep, your stress levels. With epigenetics, you're measuring that. That other 80%, you're actually looking at how much every gene is turned up and turned down. What we can predict with epigenetics is limited by our imagination and the size of the data set.”
“The Dunedin PACE. That is my favorite of the biologic age test. It's developed by Duke. And it has actually been shown to be the best predictor of morbidity and mortality period. There was a really big trial called the BASE-2 trial that just came out in the last month. And it is better than Grip Strength, VO2 Max, all the other things. It was shown to have a better predictive power.”
“In the Harvard study, we had a hypothesis, so we thought it would be really cool if we could find another dozen or two dozen of these upgraded biomarkers. Biomarkers that predict something like vitamin D or inflammation, CRP, hemoglobin A and C, but are better predictors at what you care about, which is the disease progression. And we found 1600 biomarkers we could predict when we measured them against their traditional versions.”
“And then Symphony Age tells you your different organ systems because we age in a heterogeneous way. Your brain may age faster than your liver, than your kidneys. So that then kind of tells you why you'd be aging faster or slower. Like what is the weakest link in the chain with the organ? So they tell you three very different things.”
“I basically built an AI coach for myself that I would feed in all my TruHealth data, all the stuff that we're going to talk about, all my training data, my lactate threshold stuff. And it was just cool. Yeah, I had a blast. Watching my body respond. And in the end, I think there were 34 of us that tried. We needed four of us to finish under a time to get the group world record.”
“So I, in my mind, we don't need studies on biologic age and pace of aging to know that the number one intervention over everything I'll ever tell you about, oh, they studied this supplement, they studied this medication. None of that is close to the strength of your social relationships. And I think that study was so definitive on that, that anyone who's biohacking and not focusing on that, they're wasting their time with everything else.”
“An interesting one that is not published out on this yet, but we've just seen it anecdotally, that I mean, just today, I had a fair amount of exogenous ketones. Like when we've seen, I don't have like good big studies on this, but it's pretty reliable when I've seen people do studies on themselves of, I am going to increase my ketone levels, even if it's not fasting, it's through exogenous ketones. We'll see interesting effects on pace of aging.”
“So he looked at how predictive is his epigenetic CRP, measure of inflammation, versus the traditional CRP. And he actually found it was more predictive for cognitive decline and these other things. So it was actually kind of an upgraded measure of inflammation, because it wasn't just measuring CRP, it was measuring the epigenetic effect of inflammation.”
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